SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects
Identifieur interne : 000193 ( Main/Exploration ); précédent : 000192; suivant : 000194SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects
Auteurs : Konstantinos Michalakis [Grèce] ; Ioannis Ilias [Grèce]Source :
- Diabetes & Metabolic Syndrome [ 1871-4021 ] ; 2020.
Abstract
According to the World Obesity Federation, “obesity-related conditions seem to worsen the effect of Covid-19 (SARS-CoV-2)”; additionally the Centres for Disease Control and Prevention reported that “people with heart disease and diabetes are at higher risk of SARS-CoV-2 complications and that severe obesity poses a higher risk for severe illness”. Recent reports have shown elevated levels of cytokines due to increased inflammation in patients with SARS-CoV-2 disease. On the other hand, obesity represents a state of low-grade inflammation, with various inflammatory products directly excreted by adipose tissue. In this concise report we aimed to assess common elements of obesity and SARS-CoV-2 infection.
Literature search on obesity and SARS-CoV-2 infection.
We present “mechanistic” obesity-related problems that aggravate SARS-CoV-2 infection as well as tentative inflammatory/metabolic links between these diseases.
Obesity and SARS-CoV-2 share common elements of the inflammatory process (and possibly also metabolic disturbances), exacerbating SARS-CoV-2 infection in the obese.
Url:
DOI: 10.1016/j.dsx.2020.04.033
PubMed: NONE
PubMed Central: 7189186
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects</title><author><name sortKey="Michalakis, Konstantinos" sort="Michalakis, Konstantinos" uniqKey="Michalakis K" first="Konstantinos" last="Michalakis">Konstantinos Michalakis</name><affiliation wicri:level="1"><nlm:aff id="aff1">Private Practice, 10-12 Dorylaiou Str, Athens, GR11521, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Private Practice, 10-12 Dorylaiou Str, Athens, GR11521</wicri:regionArea><wicri:noRegion>GR11521</wicri:noRegion></affiliation></author><author><name sortKey="Ilias, Ioannis" sort="Ilias, Ioannis" uniqKey="Ilias I" first="Ioannis" last="Ilias">Ioannis Ilias</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Endocrinology, Diabetes & Metabolism, Elena Venizelou Hospital, 2 Elena Venizelou Sq, Athens, GR11521, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Endocrinology, Diabetes & Metabolism, Elena Venizelou Hospital, 2 Elena Venizelou Sq, Athens, GR11521</wicri:regionArea><wicri:noRegion>GR11521</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">7189186</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189186</idno><idno type="RBID">PMC:7189186</idno><idno type="doi">10.1016/j.dsx.2020.04.033</idno><idno type="pmid">NONE</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000641</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000641</idno><idno type="wicri:Area/Pmc/Curation">000641</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000641</idno><idno type="wicri:Area/Pmc/Checkpoint">000154</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000154</idno><idno type="wicri:Area/Ncbi/Merge">001429</idno><idno type="wicri:Area/Ncbi/Curation">001429</idno><idno type="wicri:Area/Ncbi/Checkpoint">001429</idno><idno type="wicri:doubleKey">1871-4021:2020:Michalakis K:sars:cov:infection</idno><idno type="wicri:Area/Main/Merge">000193</idno><idno type="wicri:Area/Main/Curation">000193</idno><idno type="wicri:Area/Main/Exploration">000193</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects</title><author><name sortKey="Michalakis, Konstantinos" sort="Michalakis, Konstantinos" uniqKey="Michalakis K" first="Konstantinos" last="Michalakis">Konstantinos Michalakis</name><affiliation wicri:level="1"><nlm:aff id="aff1">Private Practice, 10-12 Dorylaiou Str, Athens, GR11521, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Private Practice, 10-12 Dorylaiou Str, Athens, GR11521</wicri:regionArea><wicri:noRegion>GR11521</wicri:noRegion></affiliation></author><author><name sortKey="Ilias, Ioannis" sort="Ilias, Ioannis" uniqKey="Ilias I" first="Ioannis" last="Ilias">Ioannis Ilias</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Endocrinology, Diabetes & Metabolism, Elena Venizelou Hospital, 2 Elena Venizelou Sq, Athens, GR11521, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Endocrinology, Diabetes & Metabolism, Elena Venizelou Hospital, 2 Elena Venizelou Sq, Athens, GR11521</wicri:regionArea><wicri:noRegion>GR11521</wicri:noRegion></affiliation></author></analytic><series><title level="j">Diabetes & Metabolic Syndrome</title><idno type="ISSN">1871-4021</idno><idno type="eISSN">1878-0334</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Backround and aims</title><p>According to the World Obesity Federation, “obesity-related conditions seem to worsen the effect of Covid-19 (SARS-CoV-2)”; additionally the Centres for Disease Control and Prevention reported that “people with heart disease and diabetes are at higher risk of SARS-CoV-2 complications and that severe obesity poses a higher risk for severe illness”. Recent reports have shown elevated levels of cytokines due to increased inflammation in patients with SARS-CoV-2 disease. On the other hand, obesity represents a state of low-grade inflammation, with various inflammatory products directly excreted by adipose tissue. In this concise report we aimed to assess common elements of obesity and SARS-CoV-2 infection.</p></sec><sec><title>Methods</title><p>Literature search on obesity and SARS-CoV-2 infection.</p></sec><sec><title>Results</title><p>We present “mechanistic” obesity-related problems that aggravate SARS-CoV-2 infection as well as tentative inflammatory/metabolic links between these diseases.</p></sec><sec><title>Conclusion</title><p>Obesity and SARS-CoV-2 share common elements of the inflammatory process (and possibly also metabolic disturbances), exacerbating SARS-CoV-2 infection in the obese.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="World Health Organisation Who" uniqKey="World Health Organisation Who">World Health Organisation (WHO)</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="World Health Organisation Who" uniqKey="World Health Organisation Who">World Health Organisation (WHO)</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Michalakis, K" uniqKey="Michalakis K">K. 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